Diagnosis of respiratory tract infections and associated antibiotic resistances (Respiotic)

Our point-of-care platform enables rapid and efficient patient management including an integrated electronic decision support algorithm.

The goal of the project was to achieve two disruptive changes in the respiratory tract infections (RTIs) diagnosis by shifting: (1) diagnostic methodology from empirical to molecular analysis; (2) diagnostic location from centralized lab to the point of care. Our platform enables rapid and efficient patient management including an integrated electronic decision support algorithm.

RTIs are among the top reasons for visiting a General Practitioner (GP) and the main cause of unnecessary antibiotics prescription. Reducing inappropriate use is essential to decrease antibiotic resistance and adverse events. The goal of the project was to develop a new platform, based on centrifugal microfluidics (LabDisk platform) that will detect a wide range of viruses and bacteria responsible for community-acquired RTIs, including associated resistances and host biomarkers. An electronic clinical algorithm interface was used to co-assess the test results and act as a support tool for the GPs decision on patient management and prescriptions or not. The platform (assays, microfluidics, reader and clinical algorithm) was assessed using clinical samples.

The project results are summarised in relevant peer-reviewed publications.

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