Jahr Name

Salivary Biomarkers for Dental Caries Detection and Personalized Monitoring

P.N. Paqué*, C. Herz*, D.B. Wiedemeier, K. Mitsakakis, T. Attin, K. Bao, G.N. Belibasakis, J.P. Hays, J.S. Jenzer, W.E Kaman, M. Karpíšek, P. Körner, J.R. Peham, P.R. Schmidlin, T. Thurnheer, F.J. Wegehaupt, N. Bostanci

J. Pers. Med., 2021, 11, 235. DOI: 10.3390/jpm11030235


Validation and verification of predictive salivary biomarkers for oral health

N. Bostanci, K. Mitsakakis, B. Afacan, K. Bao, B. Johannsen, D. Baumgartner, L. Müller, H. Kotolová, G. Emingil, M. Karpíšek

Scientific Reports, 2021, 11, 6406. DOI: 10.1038/s41598-021-85120-w


Rapid Detection of Pathogens in Wound Exudate via Nucleic Acid Lateral Flow Immunoassay

A. Brunauer, R. D. Verboket, D. M. Kainz, F. von Stetten, S. M. Früh

Biosensors 11 (3), 74, doi: 10.3390/bios11030074


Automated pre-analytic processing of whole saliva via magnet-beating for point-care protein biomarker analysis

B. Johannsen, L. Müller, D. Baumgartner, L. Karkossa, S. M. Früh, N. Bostanci, M. Karpíšek, R. Zengerle, N. Paust, K. Mitsakakis

Micromachines, 2019; 10:833. DOI: 10.3390/mi10120833


Fully automated point-of-care differential diagnosis of acute febrile illness

S. Hin, B. Lopez-Jimena, M. Bakheit, V. Klein, S. Stack, C. Fall, A. Sall, K. Enan, M. Mustafa, V. Rusu, S. Goethel, N. Paust, R. Zengerle, L. Gillies, S. Frischmann, M. Weidmann, K. Mitsakakis

PLoS Negl. Trop. Dis., 2021, 15(2), e0009177. DOI: 10.1371/journal.pntd.0009177


One-step, wash-free, bead-based immunoassay employing bound-free phase detection

B. Johannsen, M. Karpíšek, D. Baumgartner, V. Klein, N.Bostanci, N. Paust, S. M. Früh, R. Zengerle, K. Mitsakakis

Anal. Chim. Acta, 2021;1153:338280. DOI: 10.1016/j.aca.2021.338280


Scalable fabrication of renal spheroids and nephron-like tubules bybioprinting and controlled self-assembly of epithelial cells

K. Tröndle, L. Rizzo, R. Pichler, F. Koch, A. Itani, R. Zengerle, S. S. Lienkamp, P. Koltay, S. Zimmermann

Biofabrication …., doi: 10.1088/1758-5090/abe185


Point-of-Care System for HTLV-1 Proviral Load Quantification by Digital Mediator Displacement LAMP

L. Becherer, J. F. Hess, S. Frischmann, M. Bakheit, H. Nitschko, S. Stinco, F. Zitz, H. Hofer, G. Porro, F. Hausladen, K. Stock, D. Drossart, H. Wurm, H. Kuhn, D. Huber, T. Hutzenlaub, N. Paust, M. Keller, O. Strohmeier, S. Wadle, N. Borst, R. Zengerle, F. von Stetten

Micromachines 12 (2), 159, doi: 10.3390/mi12020159


Low-cost microfluidic catridge for the detection of myco-toxin in food to be used in a point-of-care device

D. Walter

KET4CP SME2019-06-NO.6

show abstract

This project took place in cooperation with Organska Elektronika d.o.o. and the International Iberian Nanotechnology Laboratory (INL). The company Organska Elektronika d.o.o. is developing a new system for the detection of myco-toxin in food i.e. milk. The main goals of this project were the development of a plastic catridge and the development of a portable incubator. The catridge was designed for its functionality with a simple microfluidic circuit. The middle part of the catridge can be produced by injection molding for high-volume production. Several sealing methods for the fluidic circuit were introduced. In addition a portable incubator was developed for the simultaneous use of four catridges.

Link to publication


Towards 3D-lithium ion microbatteries based on silicon/graphite blend anodes using a dispenser printing technique

M. Drews, S. Tepner, P. Haberzettl, H. Gentischer,W. Beichel, M. Breitwieser, S. Vierrath, D. Biro

RSC Adv. 10, 22440-22448, doi: 10.1039/D0RA03161E


Water Electrolyzers: All-Hydrocarbon MEA for PEM Water Electrolysis Combining Low Hydrogen Crossover and High Efficiency

C. Klose, T. Saatkamp, A. Münchinger, L. Bohn, G. Titvinidze, M. Breitwieser, K.-D. Kreuer, S. Vierrath

Adv. Energy Mater. 14, doi: 10.1002/aenm.202070061


Characterization of CRISPR/Cas9 RANKL knockout mesenchymal stem cell clones based on single-cell printing technology and emulsion coupling assay as a low-cellularity workflow for single-cell cloning

T. Groß, C. Jeney, D. Halm, G. Finkenzeller, G. B. Stark, R. Zengerle, P. Koltay, S. Zimmermann

Plos One 16 (3) e0238330, doi: 10.1371/journal.pone.0238330


Improving the Performance of All-Hydrocarbon PEM Fuel Cells Based on Pemion™ Ionomer

H. Nguyen, P. Heizmann, F. Lombeck, A. Belletti, B. Britton, S. Vierrath, M. Breitwieser

71st International Society of Electrochemistry, Belgrad, Serbia (Online), 30.08. – 04.09.2020


Towards stable catalyst layers for water electrolysis based on anion-exchange membranes

S. Koch, C. Klose, B. Britton, M. Breitwieser, S. Vierrath

71st International Society of Electrochemistry, Belgrad, Serbia (Online), 30.08. – 04.09.2020


Ceramic Nanofibers: A versatile material class to improve Electrochemical Energy Applications

F. Lombeck, F. Hegge, M. von Holst , C. Klose, S. Vierrath, M. Breitwieser

71st International Society of Electrochemistry, Belgrad, Serbia (Online), 30.08. – 04.09.2020


Performance Improvement of PEM Water Electrolyzer Anodes via a Bi-Functional Binder Polymer Blends for Ionic and Electrical Conduction

E. Cruz Ortiz, F. Hegge, M. Breitwieser, S. Vierrath

71st International Society of Electrochemistry, Belgrad, Serbia (Online), 30.08. – 04.09.2020


Exploration of a Molecularly Imprinted Polymer (MIPs) as an Adsorbent for the Enrichment of Trenbolone in Water

A. Mpupa, M. Dinc, B. Mizaikoff und P. N. Nomngongo

Processes 2021, 9, 186, Link to publication

show abstract

The presence of endocrine disruptors in surface waters can have negative implications on wildlife and humans both directly and indirectly. A molecularly imprinted polymer (MIP) was explored for its potential to enhance the UV-Vis determination of trenbolone in water using solid phase extraction (SPE). The synthesized MIP was studied using Fourier transform infrared spectra (FTIR) and scanning electron microscopy (SEM). Using the MIP resulted in a preconcentration and enrichment factor of 14 and 8, respectively. Trenbolone binding on the MIP was shown to follow a Langmuir adsorption and had a maximum adsorption capacity of 27.5 mg g-1. Interference studies showed that the MIP selectivity was not compromised by interferences in the sample. The MIP could be recycled three times before significant loss in analyte recovery.


High Dynamic Range Digital Assay Enabled by Dual-Volume Centrifugal Step Emulsification

M. Schulz, J. Ruediger, E. Landmann, M. Bakheit, S. Frischmann, D. Rassler, A. Homann, F. von Stetten, R. Zengerle, N. Paust

Anal. Chem. ….., doi: 10.1021/acs.analchem.0c04182


Centrifugal Microfluidic Integration of 4-Plex ddPCR Demonstrated by the Quantification of Cancer-Associated Point Mutations

F. Schlenker, E. Kipf, N. Borst, N. Paust, R. Zengerle, F. von Stetten, P. Juelg, T. Hutzenlaub

Processes 2021, 9 (97), doi: 10.3390/pr9010097


The MRD disk: automated minimal residual disease monitoring by highly sensitive centrifugal microfluidic multiplex qPCR

P. Juelg, E. Kipf, M. Specht, M. Fillies, C. Eckert, N. Paust, R. Zengerle, M. Lehnert, T. Hutzenlaub

LabChip …. doi: 10.1039/d0lc00945h